Cathepsin, Calpain & Granzyme B Activity Assay and Inhibitor Screening Kits

Apoptosis can be mediated by mechanisms other than the traditional caspase-mediated cleavage cascade. There is growing knowledge that alternative proteolytic enzymes such as the lysosomal cathepsin proteases may initiate or propagate proapoptotic signals, but it is currently unclear how cathepsin mediates apoptosis.  The serine protease Granzyme B is produced in cytotoxic T and NK cells, enters the target cell where it inducies apoptosis.