Caspase Kits & Reagents

Caspases, a family of cysteine aspartic acid proteases, are important factors in the progression of apoptosis and can be activated by various deleterious and physiologic stimuli such as cytochrom c release due to mitochondrial membrane disruption, DNA damage, ER stress or other inducers such as TNF-alpha and FasL. Caspases are normally present in the cell as inactive pro-enzymes. During apoptosis, they are activated by proteolysis forming a proteolytic cascade that results in the cleavage of distinct proteins that are mostly essential for the cell's viability.