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Cytokines and Growth Factors for Stem Cell Research

Stem cells play a central role in the development of multicellular organisms and diverse regeneration processes throughout their lifes, e.g. replacing diseased and damaged tissues. They are unspecialized precursor cells characterized by their abilities of self-renewal and pluripotency, that means they can undergo numerous rounds of cell division maintaining the undifferentiated state and are able to develop into different types of cells such as skin, muscle or blood cells.

Mammalian stem cells are generally comprised of two types: Embryonic stem cells (ESCs) are derived from the epiblast tissue of the inner cell mass of an early stage embryo (blastocyst) and are considered pluripotent and capable to differentiate into any cell type of the adult body. Adult stem cells (also known as somatic stem cells) are undifferentiated cells found in the tissues of children and adults. Their main function is to replace dead or damaged specialiced cells and to maintain the normal turnover of regenerative organs. Most adult stem cells are lineage-restricted (multipotent) and characterized by a limited self-renewal and differentiation capacity usually restricted to cell types of the tissue in which they reside. In contrast, induced pluripotent stem cells (iPSCs) are not adult stem cells but specialised, somatic adult cells (e.g. epithelial cells) that have been genetically reprogrammed to pluripotent cells which are in many respects similar to natural pluripotent stem cells such as embryonic stem cells.

 

PromoKine provides a variety of cytokines and growth factors important in stem cell research:

Please note that our animal-free cytokines and growth factors derived from plant cells are particularly well suited for stem cell research as they have extremely low endotoxin levels (compared to proteins produced in E. coli) and are also free of any unwanted contamination derived from production in mammalian cell culture. Endotoxins are known to affect different cellular processes such as cell proliferation and cell differentiation leading to biassed results.
We now also provide endotoxin-free HSA derived from plant cells that can be used as carrier protein for long-term storage of cytokines and growth factors in solution.

See also:

Antibodies for Stem Cell Research

Human Stem & Blood Cells

Media for Human Stem & Blood Cells