Products

Cytokines, Growth Factors, CD Antigens & Soluble Receptors

All cytokines, chemokines, growth factors, CD antigens and soluble receptors available from PromoKine meet the highest quality expectations. They are highly purified and biologically active - of course we want to offer you optimal biological activity not only protein concentrations. Purity is generally assessed e.g. by SDS-PAGE and HPLC analysis and is in most cases higher than 98%. Most of the products are delivered lyophilized at RT and some come ready to use in a buffer solution. Reconstitution of the lyophilized proteins should be carried out in water or common buffer solutions.


Animal-free Cytokines & Growth Factors

PromoKine's animal-free cytokines and growth factors have been produced by molecular farming using barley grain or tobacco plants as production host - which has also the G.R.A.S. (Generally Recognized As Safe) status from the FDA. 
These cytokines are free of animal components, serum, endotoxins and antibiotics as well as human or animal infectious agents or other endogenous mammalian contamination (e.g. traces of unwanted growth factors and cytokines). As these proteins have been expressed in barley seed endosperm or tobacco plants, they show very low proteolytic, pyrogenic and inflammatory activity compared to other commercially available proteins produced in bacteria, yeast, insect or mammalian cells. In addition, they retain proper eukaryotic folding and glycosylation resulting in an increased stability and biological activity. Degradation due to protease carryover as well as unwanted cell responses (e.g. proliferation, chemokine release and inflammatory cascades) or cell growth inhibition caused by contaminating serum components (serum carryover), endotoxins or bacterial, viral and prion infectious agents are eliminated or at least extremely reduced. See Product List

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Research Grade

The research grade products are suitable for a variety of applications in cell culture, as media supplements, for assay development and as controls. It is the standard quality for all of our products that have passed an extensive quality control. They are sterile-filtered with endotoxin levels below 0.1 ng/µg (<1EU/µg) and purities that are generally higher than 95%. The biological activity has been tested in appropriate bioassays and typically a minimum activity is guaranteed. Otherwise the ED50 or an optimal concentration range are given. For some only recently released products, some data are not yet available.

Cell Culture Grade (CC)

The cell culture grade products are lyophilized with medium, DIMEM/F12 and FCS. They are optimal for certain applications where the direct reconstitution with water to a solution containing medium is favourable (direct media solution).

 

Beside our standard sizes, we also provide bulk sizes at very favorable prices. Please request!

 

 

 

 

  

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