Products

Active Cathepsins, Procathepsins, Calpain & Granzyme B

Caspases are the most important proteases associated with apoptosis. However, apoptosis can also be mediated by mechanisms other than the traditional caspase-mediated cleavage cascade. There is growing knowledge that alternative proteolytic enzymes such as the lysosomal cathepsin proteases or calpain may initiate or propagate proapoptotic signals, but it is currently unclear how they mediate apoptosis. Cathepsins are lysosomal enzymes that are also used as sensitive markers in various toxicological investigations. Calpain is involved in many physiological and pathological processes (e.g. apoptosis/necrosis and cell cycle).

Granzyme B is a serine protease released from cytotoxic T and NK cells and mediates apoptosis by activating Caspase-3 and Caspase-7. It is also involved in inflammatory processes and autoimmune diseases. 

PromoKine offers a range of Cathepsin/Calpain/Granzyme B Activity Assay and Cathepsin/Calpain/Granzyme B Inhibitor Screening Kits as well as Cathepsin, Calpain and Granzyme B substrates and inhibitors.

 

 

Product Name Description Size Catalog Number Information Prices
Procathepsin B, human, recombinant Recombinant Human Procathepsin B 10 µg PK-RP577-7579-10 click to select country
Procathepsin B, human, recombinant Recombinant Human Procathepsin B 50 µg PK-RP577-7579-50 click to select country
Cathepsin B, human, recombinant Recombinant Human Cathepsin B (active) 5 µg PK-RP577-7580-5 click to select country
Cathepsin B, human, recombinant Recombinant Human Cathepsin B (active) 50 µg PK-RP577-7580-50 click to select country
Cathepsin D, human, recombinant RecombinantHuman Cathepsin D (active) 10 µg PK-RP577-7409-10 click to select country
Cathepsin G, human (native) Active Cathepsin G derived from human neutrophils 100 µg PK-RP577-4713-100 click to select country
Calpain-1, human, (native) Active Human Calpain 1 100 µg PK-RP577-1134 click to select country
Procathepsin K, human, recombinant Human recombinant Procathepsin K 50 µg PK-RP577-1026-50 click to select country
Procathepsin K, mouse, recombinant Mouse recombinant Procathepsin K 50 µg PK-RP577-1027-50 click to select country
Procathepsin K, rat, recombinant Recombinant Rat Procathepsin K 10 µg PK-RP577-1029-10 click to select country
Procathepsin K, rat, recombinant Recombinant Rat Procathepsin K 50 µg PK-RP577-1029-50 click to select country
Cathepsin K, human, recombinant Recombinant Human Cathepsin K (active) 5 µg PK-RP577-7600-5 click to select country
Cathepsin K, mouse, recombinant recombinant Recombinant Mouse Cathepsin K (active) 5 µg PK-RP577-7597-5 click to select country
Cathepsin B, human (native) native Active Human Cathepsin B 5 µg PK-RP577-1021 click to select country
Cathepsin D, human (native) native Active Human Cathepsin D 5 µg PK-RP577-1022 click to select country
Cathepsin H, human (native) native Active Human Cathepsin H 5 µg PK-RP577-1023 click to select country
Cathepsin L, human, recombinant Active Human Cathepsin L 100 µg PK-RP577-1135-100 click to select country
Cathepsin L, human, recombinant Active Human Cathepsin L 5 µg PK-RP577-1135-5 click to select country
Procathepsin K, human, recombinant Human recombinant Procathepsin K 10 µg PK-RP577-1026-10 click to select country
Procathepsin K, mouse recombinant Mouse recombinant Procathepsin K 10 µg PK-RP577-1027-10 click to select country
Cathepsin K, rat, recombinant recombinant Recombinant Rat Cathepsin K (active) 5 µg PK-RP577-7598-5 click to select country
Procathepsin L, human, recombinant Recombinant Human Procathepsin L 5 µg PK-RP577-7581-5 click to select country
Procathepsin L, human, recombinant Recombinant Human Procathepsin L 100 µg PK-RP577-7581-100 click to select country
Procathepsin S, human, recombinant Recombinant Human Procathepsin S 10 µg PK-RP577-7525-10 click to select country
Procathepsin S, human, recombinant Recombinant Human Procathepsin S 50 µg PK-RP577-7525-50 click to select country
Cathepsin S, human, recombinant Recombinant Human Cathepsin S (active) 10 µg PK-RP577-7526-10 click to select country
Cathepsin S, human, recombinant Recombinant Human Cathepsin S (active) 50 µg PK-RP577-7526-50 click to select country
Granzyme B, mouse, recombinant Recombinant Mouse Granzyme B 10 µg D-69156 click to select country