- Staining of viable and dead cells
- Detection of cellular structures
- Suited for e.g. fluorescence microscopy/flow cytometry
- High quality
- Thoroughly tested
- Highly sensitive
Membrane Potential Sensitive Dyes
These dyes change their fluorescence when there is a change in the membrane potential of the cell to which they are bound. These voltage-sensitive dyes have been divided into slow dyes and fast dyes. The slow dyes respond to membrane potential changes with a time constant of milliseconds to seconds and have been used for e.g. to measure the resting potential of large populations of identical cells. Their slow response time makes them unsuitable for recording the more rapid kinds of neuronal activity. The fast dyes respond in microseconds with optical signals that are linearly related to changes in membrane potential. They can be used for example to monitor membrane potential changes in mitochondria, or in processes of individual neurons.