Products

Caspase Inhibitors

Our caspase inhibitors come in ready-to-use form and can be used with PromoKine's  caspase assays as well as any other caspase assays. They are very useful for setting up your own assays together with our ready-to-use active caspases and caspase substrates.

In addition to our classical FMK inhibitors, we are also providing the next generation of capase inhibitors: Q-VD-OPh (Quinolyl-Valyl-O-methylaspartyl-[2,6-difluorophenoxy]-methyl ketone) is a cell-permeable, irreversible, broad spectrum caspase inhibitor that displays higher potency (with IC50 values for caspases -1, -3, -8, -9, -10, and -12 in the range of 25-400 nM), less toxicity, and longer stability than the FMK inhibitors, making it a useful tool for both in vitro and in vivo studies. Q-VD-OPh is more effective in preventing apoptosis than the commonly used pan-caspase inhibitor, Z-VAD-FMK.

References, Questions & Answers

Product Name Description Size Catalog Number Information Prices
Biotin-VDVAD-FMK (10 mM) Biotinylated derivative of the Caspase-2 inhibitor Z-VDVAD-FMK 20 µl PK-CA577-1032-20C click to select country
Biotin-DEVD-FMK (10 mM) Irreversibly inhibits activity of caspase-3 and related caspases and blocks apoptosis 20 µl PK-CA577-1124-20C click to select country
Biotin-IETD-FMK (10 mM) Recommend to use at 1000-5000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.) 20 µl PK-CA577-1121-20C click to select country
Biotin-VAD-FMK (10 mM) Irreversibly inhibits activity of caspase family proteases and blocks apoptosis 20 µl PK-CA577-1123-20C click to select country
Caspase Family in vivo Inhibitor Q-VD-OPH Caspase family in vivo inhibitor 1 mg PK-CA577-1170-1 click to select country
Caspase Family in vivo Inhibitor Q-VD-OPH Caspase family in vivo inhibitor 5 mg PK-CA577-1170-5 click to select country
Caspase Family Inhibitor Boc-D-FMK Caspase family in vivo inhibitor 1 mg PK-CA577-1160-1 click to select country
Caspase Family Inhibitor Boc-D-FMK Caspase family in vivo inhibitor 5 mg PK-CA577-1160-5 click to select country
Caspase Family Inhibitor Z-VAD-FMK Caspase family in vivo inhibitor 1 mg PK-CA577-1140-1 click to select country
Caspase Family Inhibitor Z-VAD-FMK Caspase family in vivo inhibitor 5 mg PK-CA577-1140-5 click to select country
Caspase-1 Inhibitor Z-YVAD-FMK Caspase-1 Inhibitor 1 mg PK-CA577-1141-1 click to select country
Caspase-1 Inhibitor Z-YVAD-FMK Caspase-1 Inhibitor 5 mg PK-CA577-1141-5 click to select country
Caspase-1 Inhibitor Z-YVAD-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1012-20C click to select country
Caspase-1 Inhibitor Z-YVAD-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1012-100 click to select country
Caspase-10 Inhibitor AEVD-FMK Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1112-100 click to select country
Caspase-10 Inhibitor AEVD-FMK Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1112-20C click to select country
Caspase-12 Inhibitor Z-ATAD-FMK Recommend to use at 1:1000 dilutions for tissue and cell lysate 100 µl PK-CA577-1079-100 click to select country
Caspase-12 Inhibitor Z-ATAD-FMK Recommend to use at 1:1000 - 1:5000 dilutions for cell culture 20 µl PK-CA577-1079-20C click to select country
Caspase-12 Inhibitor Z-ATAD-FMK Caspase-12 Inhibitor 1 mg PK-CA577-1152-1 click to select country
Caspase-12 Inhibitor Z-ATAD-FMK Caspase-12 Inhibitor 5 mg PK-CA577-1152-5 click to select country
Caspase-13 Inhibitor LEED-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1115-20C click to select country
Caspase-13 Inhibitor LEED-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1115-100 click to select country
Caspase-2 Inhibitor Z-VDVAD-FMK Caspase-2 Inhibitor 1 mg PK-CA577-1142-1 click to select country
Caspase-2 Inhibitor Z-VDVAD-FMK Caspase-2 Inhibitor 5 mg PK-CA577-1142-5 click to select country
Caspase-2 Inhibitor Z-VDVAD-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1073-20C click to select country
Caspase-2 Inhibitor Z-VDVAD-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1073-100 click to select country
Caspase-3 Inhibitor Q-DEVD-OPh Q-DEVD-OPh 1 mg PK-CA577-1175-1 click to select country
Caspase-3 Inhibitor Q-DEVD-OPh Q-DEVD-OPh 5 mg PK-CA577-1175-5 click to select country
Caspase-3 Inhibitor Z-DEVD-FMK Caspase-3 Inhibitor 1 mg PK-CA577-1143-1 click to select country
Caspase-3 Inhibitor Z-DEVD-FMK Caspase-3 Inhibitor 5 mg PK-CA577-1143-5 click to select country
Caspase-3 Inhibitor Z-DEVD-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1009-20C click to select country
Caspase-3 Inhibitor Z-DEVD-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1009-100 click to select country
Caspase-4 Inhibitor Z-LEVD-FMK Caspase-4 Inhibitor 1 mg PK-CA577-1144-1 click to select country
Caspase-4 Inhibitor Z-LEVD-FMK Caspase-4 Inhibitor 5 mg PK-CA577-1144-5 click to select country
Caspase-4 Inhibitor Z-LEVD-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1108-20C click to select country
Caspase-4 Inhibitor Z-LEVD-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1108-100 click to select country
Caspase-5 Inhibitor Z-WEHD-FMK Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1100-100 click to select country
Caspase-5 Inhibitor Z-WEHD-FMK Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1100-20C click to select country
Caspase-6 Inhibitor Z-VEID-FMK Caspase-6 Inhibitor 1 mg PK-CA577-1146-1 click to select country
Caspase-6 Inhibitor Z-VEID-FMK Caspase-6 Inhibitor 5 mg PK-CA577-1146-5 click to select country
Caspase-6 Inhibitor Z-VEID-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1011-20C click to select country
Caspase-6 Inhibitor Z-VEID-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1011-100 click to select country
Caspase-8 Inhibitor Z-IETD-FMK Caspase-8 Inhibitor 1 mg PK-CA577-1148-1 click to select country
Caspase-8 Inhibitor Z-IETD-FMK Caspase-8 Inhibitor 5 mg PK-CA577-1148-5 click to select country
Caspase-8 Inhibitor Z-IETD-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1064-20C click to select country
Caspase-8 Inhibitor Z-IETD-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1064-100 click to select country
Caspase-8 Inhibitor, Q-IETD-Oph Q-IE(OMe)-TD(OMe)-OPh; Quinolyl-Ile-Glu(OMe)-Thr-Asp(OMe)-OPh 1 mg PK-CA577-1176-1 click to select country
Caspase-8 Inhibitor, Q-IETD-Oph Q-IE(OMe)-TD(OMe)-OPh; Quinolyl-Ile-Glu(OMe)-Thr-Asp(OMe)-OPh 5 mg PK-CA577-1176-5 click to select country
Caspase-9 Inhibitor Z-LEHD-FMK Caspase-9 Inhibitor 1 mg PK-CA577-1149-1 click to select country
Caspase-9 Inhibitor Z-LEHD-FMK Caspase-9 Inhibitor 5 mg PK-CA577-1149-5 click to select country
Caspase-9 Inhibitor Z-LEHD-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1074-20C click to select country
Caspase-9 Inhibitor Z-LEHD-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1074-100 click to select country
Caspase-9 Inhibitor, Q-LEHD-Oph Q-LE(OMe)-HD(OMe)-OPh; Quinolyl-Leu-Glu(OMe)-His-Asp(OMe)-OPh 1 mg PK-CA577-1177-1 click to select country
Caspase-9 Inhibitor, Q-LEHD-Oph Q-LE(OMe)-HD(OMe)-OPh; Quinolyl-Leu-Glu(OMe)-His-Asp(OMe)-OPh 5 mg PK-CA577-1177-5 click to select country
Caspase-Family Inhibitor Boc-D-FMK (10 mM) Recommend to use at 1:1000 - 1:5000 dilutions for cell culture 20 µl PK-CA577-1120-20C click to select country
Caspase-Family Inhibitor Set Contains Caspase-1/-3/-6/-8 Family Inhibitors 5 x 25 µl PK-CA577-K107 click to select country
Caspase-Family Inhibitor Set II Contains Caspase-1/-2/-3/-6/-8/-9 Family Inhibitors 7 x 25 µl PK-CA577-K108 click to select country
Caspase-Family Inhibitor Set III Contains Caspase-1/-2/-3/-5/-6/-8/-9 Family Inhibitors 8 x 25 µl PK-CA577-K210 click to select country
Caspase-Family Inhibitor Set IV Contains Caspase-1/-2/-3/-4/-5/-6/-8/-9/-10/-13 Family Inhibitors/FMK Negative Control 12 x 25 µl PK-CA577-K220 click to select country
Caspase-Family Inhibitor Z-VAD-FMK (10 mM) Recommend to use at up to 1:5000 dilutions for cell culture 20 µl PK-CA577-1010-20C click to select country
Caspase-Family Inhibitor Z-VAD-FMK (2 mM) Recommend to use at 1:1000 dilutions for cell culture 100 µl PK-CA577-1010-100 click to select country
FMK Negative Control (for caspase inhibitors; 2 mM) Recommended to use at 1000X dilutions for cell culture 100 µl PK-CA577-1122-100 click to select country
FMK Negative Control (for caspase inhibitors;10 mM) Recommended to use at up to 5000X dilutions for cell culture 20 µl PK-CA577-1122-20C click to select country
Q-VD-OPH Negative Control Caspase in vivo inhibitor 1 mg PK-CA577-1171-1 click to select country
Q-VD-OPH Negative Control Caspase in vivo inhibitor 5 mg PK-CA577-1171-5 click to select country


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